2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-129105A
    Chlormethiazole (edisylate) 1867-58-9 98%
    Chlormethiazole (edisylate) is a sedative-hypnotic with active allosteric modulatory activity at GABAA receptors.
    Chlormethiazole (edisylate)
  • HY-129138R
    Cyanidin 3,5-diglucoside chloride (Standard) 2611-67-8
    Cyanidin 3,5-diglucoside (chloride) (Standard) is the analytical standard of Cyanidin 3,5-diglucoside (chloride). This product is intended for research and analytical applications. Cyanidin 3,5-diglucoside chloride is a type of anthocyanin. Cyanidin 3,5-diglucoside chloride inhibits hyperbaric pressure-induced GLAST decrease. Cyanidin 3,5-diglucoside chloride has the potential for the research of glaucoma.
    Cyanidin 3,5-diglucoside chloride (Standard)
  • HY-129468R
    Pirimiphos ethyl (Standard) 23505-41-1
    Pirimiphos ethyl (Standard) is the analytical standard of Pirimiphos ethyl. This product is intended for research and analytical applications. Pirimiphos ethyl is a kind of organophosphorus pesticide that commonly employes for the protection of crops including vegetables, bananas, turf and mushrooms through the inhibition of acetylcholinesterase activity.
    Pirimiphos ethyl (Standard)
  • HY-129566R
    Withanolide B (Standard) 56973-41-2
    Withanolide B (Standard) is the analytical standard of Withanolide B. This product is intended for research and analytical applications. Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects.
    Withanolide B (Standard)
  • HY-129692R
    Withanone (Standard) 27570-38-3
    Withanone (Standard) is the analytical standard of Withanone (HY-129692). This product is intended for research and analytical applications. Withanone is an active ingredient from the roots of Withania somnifera and a GRP75 inhibitor. Withanone has multifunctional neuroprotective effects in alleviating cognitive dysfunction. In neuron-like cells, Withanone can inhibit NMDA-induced excitotoxicity. Withanone can inhibit white adipose tissue browning by blocking the formation of the GRP75-ANT2-UCP1 complex, thereby alleviating cancer-related cachexia. Withanone can be used in the research of tumors and nervous system diseases.
    Withanone (Standard)
  • HY-129864A
    4-APDB hydrochloride 1203342-42-0 98%
    4-APDB hydrochloride is a benzofuran.
    4-APDB hydrochloride
  • HY-12987S2
    Pimozide-d4-1 98%
    Pimozide-d4-1 is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.
    Pimozide-d4-1
  • HY-129923R
    (R)-Omeprazole sodium (Standard) 161796-77-6
    (R)-Omeprazole (sodium) (Standard) is the analytical standard of (R)-Omeprazole (sodium). This product is intended for research and analytical applications. (R)-Omeprazole sodium is a gastric acid resistant compound with activity to inhibit gastric acid secretion. (R)-Omeprazole sodium is metabolized in vivo, and its metabolism is primarily affected by cytochrome P450 enzymes. The interaction between (R)-Omeprazole sodium and mannitol may affect its bioavailability in formulations. (R)-Omeprazole sodium exhibits reversible direct and metabolism-dependent inhibition of CYP2C19.
    (R)-Omeprazole sodium (Standard)
  • HY-130239A
    (±)14-HDHA 87042-40-8 98%
    (±)14-HDHA is the isomer of 14(S)-HDHA (HY-130239). 14(S)-HDHA is an oxygenation product of Docosahexaenoic acid (DHA). 14(S)-HDHA is a marker reflecting activation of a Docosahexaenoic acid carbon 14-lipoxygenation pathway.
    (±)14-HDHA
  • HY-131286A
    Talaglumetad hydrochloride 441765-97-5 98%
    Talaglumetad hydrochloride is a precursor of thetype II metabotropic glutamate receptor (mGluR2/3) agonist Eglumegad for the research of anxiety.
    Talaglumetad hydrochloride
  • HY-131479A
    Threo-dihydrobupropion 153365-82-3 98%
    Threo-dihydrobupropion is a major metabolite of Bupropion, formed via oxidation and reduction exhibit pharmacological activity. Bupropion, a dual dopamine-norepinephrine uptake inhibitor and a nicotine receptor antagonist, is widely used in the management of depression and as a smoking cessation aid.
    Threo-dihydrobupropion
  • HY-131897S
    1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol 2692624-31-8 98%
    1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol is the deuterium labeled 1-Stearoyl-2-arachidonoyl-sn-glycerol. 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity.
    1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol
  • HY-13204S1
    rel-Biperiden-d5 98%
    rel-Biperiden-d5 is deuterium labeled Biperiden (hydrochloride).
    rel-Biperiden-d5
  • HY-13204S2
    rel-Biperiden EP impurity A-d5 98%
    rel-Biperiden EP impurity A-d5 is deuterium labeled Biperiden (hydrochloride).
    rel-Biperiden EP impurity A-d5
  • HY-13204S3
    rel-Biperiden EP impurity B-d5 98%
    rel-Biperiden EP impurity B-d5 is deuterium labeled Biperiden (hydrochloride).
    rel-Biperiden EP impurity B-d5
  • HY-132280R
    Tirilazad (Standard) 110101-66-1
    Estradiol enanthate (Standard) is the analytical standard of Estradiol enanthate. This product is intended for research and analytical applications. Estradiol enanthate is a shorter-acting estrogen. The combination of Estradiol enanthate and dihydroxyprogesterone acetophenide can be used as a monthly injectable contraceptive.
    Tirilazad (Standard)
  • HY-132409S
    Monocrotophos-d6 1795136-77-4 98%
    Monocrotophos-d6 is the deuterium labeled Monocrotophos. Monocrotophos. Monocrotophos is an organophosphate insecticide with broad application in crops. Monocrotophos inhibits the activity of the acetylcholine esterase (AChE) enzyme and affects the neurotransmission between neurons.
    Monocrotophos-d6
  • HY-132821A
    Irsenontrine maleate 1630083-70-3 98%
    Irsenontrine (E2027) maleate is an orally active and selective phosphodiesterase 9 (PDE9) inhibitor. Irsenontrine maleate can be used for the research of neurological diseases.
    Irsenontrine maleate
  • HY-132821B
    (R)-Irsenontrine 1429509-81-8 99.00%
    (R)-Irsenontrine ((R)-E2027), the R-enantiomer of Irsenontrine (HY-132821), is a potent phosphodiesterase 9 (PDE9) inhibitor with an IC50 value of 0.041 μM. (R)-Irsenontrine can be used for the research of neurological diseases.
    (R)-Irsenontrine
  • HY-133092R
    Perphenazine sulfoxide (Standard) 10078-25-8
    Perphenazine sulfoxide (Standard) is the analytical standard of Perphenazine sulfoxide. This product is intended for research and analytical applications. Perphenazine sulfoxide is a sulphoxide metabolite of Perphenazine, formed by the oxidation of Perphenazine.
    Perphenazine sulfoxide (Standard)
Cat. No. Product Name / Synonyms Application Reactivity